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Company Description
Precision BioSciences, Inc. is a clinical-stage biotechnology company pioneering a novel and proprietary genome editing platform, ARCUS, to develop a new class of in vivo gene editing medicines designed to overcome and potentially cure hardtotreat conditions, including rare genetic diseases. Discovered and developed by Precision scientists, ARCUS employs sequencespecific DNAcutting enzymes (nucleases) to knock in, knock out, or repair DNA in living cells and tissues, enabling targeted and durable therapeutic approaches. The companys lead program, PBGENEHBV, is a firstinclass therapeutic for chronic hepatitis B that applies a dual mechanism intended to eliminate cccDNA and inactivate integrated HBV DNA; it is advancing through the ELIMINATEB clinical trial with emerging safety, tolerability, and dosedependent antiviral activity and has received U.S. FDA Fast Track designation, clinical trial approvals in multiple regions, and an expanding clinical footprint. Precision is also progressing PBGENEDMD for Duchenne muscular dystrophy, which has been granted FDA Rare Pediatric Disease and Orphan Drug designations, and PBGENEPMM aimed at primary mitochondrial myopathy, supported by peerreviewed data in Nature Metabolism and presentations at leading scientific meetings. Beyond its wholly owned pipeline, the company collaborates with industry leaders, including Novartis on in vivo gene editing for disorders such as sickle cell disease, iECURE on an ARCUS gene insertion program in OTC deficiency (ECUR506) with encouraging clinical updates, and TG Therapeutics and Imugene on its allogeneic CAR T legacy asset AzerCel in autoimmune diseases and oncology. Precision regularly shares progress through press releases, scientific publications, and conference presentations (EASL, ASGCT, MDA, ESGCT, HEPDART), and provides comprehensive investor resources, governance materials, and a corporate deck via its investor portal. Guided by a mission of advancing science, curing genetic disease, and restoring hope, the company pairs rigorous research with disciplined clinical execution and strategic partnering to translate the unique capabilities of ARCUS into potentially curative, firstinclass therapeutics across virology, neuromuscular, and mitochondrial disease areas.
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